反应详情

200 mg 7-(3-fluoro-4-trifluormethoxy-phenyl)-[1,6]-naphthyridine-5-ol (5.1) and 10 μL N,N-diethylaniline were stirred into 4 mL phosphorus oxychloride overnight at 120° C. The reaction mixture was evaporated down, followed by co-evapoartion with toluene (×3) and the residue purified via silica gel chromatography (ethyl acetate→dichloromethane/methanol 4:1).

1. customThe reaction mixture was evaporated down
2. customthe residue purified via silica gel chromatography (ethyl acetate→dichloromethane/methanol 4:1)