Trifluoroacetic acid → HCID 178525685, compound

HRID 870568Notes

Reaction equation

HRID 870568 reaction equation
[NH:1]1[C:5]([CH2:6][CH2:7][O:8][CH2:9][C:10]([O:12]C(C)(C)C)=[O:11])=[CH:4][N:3]=[N:2]1.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>ClCCl>[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[NH:1]1[C:5]([CH2:6][CH2:7][O:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:4][N:3]=[N:2]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178451356HCID 178451356, compound

Product 1

HCID 178525685HCID 178525685, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Stir a mixture of tert-butyl 2-[2-(1H-triazol-5-yl)ethoxy]acetate (14.15 g; 62.26 mmol) and trifluoroacetic acid (70.75 mL, 935.69 mmol) in dichloromethane (70.75 mL) for 2 hours at room temperature. Concentrate the reaction mixture under reduced pressure to provide the title compound containing additional trifluoroacetic acid (20.22 g, >100%) as a brown solid. MS (m/z): 172.05 (M+1).

Workup

  1. concentrationConcentrate the reaction mixture under reduced pressure

Sources & evidence

ORD record
ord-470d31da017f40f5a643b89f8f635001
Source dataset
uspto-grants-2015_03
Patent number
US08969555B2

Reaction notes

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