Hydrochloric Acid → HCID 178524960, compound

HRID 870614Notes

Reaction equation

HRID 870614 reaction equation
[CH2:1]([N:8]1[C:12]([OH:13])=[C:11]([C:14]([O-:16])=[O:15])[N:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].Cl>>[CH2:1]([N:8]1[C:12]([OH:13])=[C:11]([C:14]([OH:16])=[O:15])[N:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178524959HCID 178524959, compound

Product 1

HCID 178524960HCID 178524960, compoundYield 89%

Procedure

Stir a 90° C. solution of 1-benzyl-5-hydroxy-1H-1,2,3-triazole-4-carboxylate (1.46 g; 1.0 equiv; 5.90 mmoles) and sodium hydroxide (1N; 10.00 mL; 1.7 equiv; 10.00 mmoles) for 9 hours. Add 1N hydrochloric acid until the pH is 2, then filter the reaction and dry the filter cake to afford 1-benzyl-5-hydroxy-1H-1,2,3-triazole-4-carboxylic acid (1.15 g; 89%): MS (m/z): 220(M+1).

Workup

  1. filtrationfilter
  2. customthe reaction
  3. customdry the filter cake

Sources & evidence

ORD record
ord-2a057a448b984e96bfa78e0e974eddba
Source dataset
uspto-grants-2015_03
Patent number
US08969555B2

Reaction notes

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