Allylamine → HCID 86696410, compound

HRID 870708Notes

Reaction equation

HRID 870708 reaction equation
[Br:1][C:2]1[N:6]2[N:7]=[C:8](Cl)[CH:9]=[CH:10][C:5]2=[N:4][CH:3]=1.[CH2:12]([NH2:15])[CH:13]=[CH2:14]>>[CH2:12]([NH:15][C:8]1[CH:9]=[CH:10][C:5]2[N:6]([C:2]([Br:1])=[CH:3][N:4]=2)[N:7]=1)[CH:13]=[CH2:14]

Participants

3

Reactant 2

HCID 7853AllylamineHCID 128723233-Bromo-6-chloroimidazo(1,2-b)pyridazine

Product 1

HCID 86696410HCID 86696410, compoundYield 51%

Procedure

A solution of 3-bromo-6-chloroimidazo[1,2-b]pyridazine (1000 mg, 4.32 mmol) and allylamine (6.0 mL, 80 mmol) was heated at 80° C. (sealed tube) for 6 h. The resulting mixture was cooled to room temperature and purified on silica gel (eluting with ethyl acetate) to afford N-allyl-3-bromoimidazo[1,2-b]pyridazin-6-amine (550 mg, 51% yield) as a yellow solid: LRMS (ESI) m/z 253.0, 255.0 [(M+H)+, calcd for C9H9BrN4 252.0]

Workup

  1. custom(sealed tube) for 6 h
  2. custompurified on silica gel (eluting with ethyl acetate)

Sources & evidence

ORD record
ord-22dd11e3346041f697813bc22aeeb0da
Source dataset
uspto-grants-2015_03
Patent number
US08969565B2

Reaction notes

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