Hydrochloric Acid → HCID 86696471, compound

HRID 870763Notes

Reaction equation

HRID 870763 reaction equation
[ClH:1].[Br:2][C:3]1[N:7]2[N:8]=[C:9]([N:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH:13]3[CH3:25])[CH:10]=[CH:11][C:6]2=[N:5][CH:4]=1>CO>[ClH:1].[ClH:1].[Br:2][C:3]1[N:7]2[N:8]=[C:9]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH:13]3[CH3:25])[CH:10]=[CH:11][C:6]2=[N:5][CH:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86696473HCID 86696473, compound

Product 1

HCID 86696471HCID 86696471, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Concentrated hydrochloric acid (3.0 mL) was added to a solution of tert-butyl 4-(3-bromoimidazo[1,2-b]pyridazin-6-yl)-3-methylpiperazine-1-carboxylate (1.2 g, 3.1 mmol) in methanol (60 mL) and allowed to stir at ambient temperature under N2 blanket for 3d. The solution was then evaporated to dryness to provide 1.1 g of light brown solid. LRMS (ESI) m/z 295.9/297.9 [(M+H)]+, calc'd for C11H14BrN5. 296.17.

Workup

  1. customThe solution was then evaporated to dryness
  2. customto provide 1.1 g of light brown solid

Sources & evidence

ORD record
ord-2f7348a031dc461988474b7b5b36ba2a
Source dataset
uspto-grants-2015_03
Patent number
US08969565B2

Reaction notes

Loading…