Hydrazine hydrate (1:1) → HCID 86696493, compound

HRID 870785Notes

Reaction equation

HRID 870785 reaction equation
[Br:1][C:2]1[N:6]2[N:7]=[C:8](F)[CH:9]=[CH:10][C:5]2=[N:4][CH:3]=1.O.[NH2:13][NH2:14]>>[Br:1][C:2]1[N:6]2[N:7]=[C:8]([NH:13][NH2:14])[CH:9]=[CH:10][C:5]2=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 866963183-Bromo-6-fluoroimidazo[1,2-b]pyridazine

Product 1

HCID 86696493HCID 86696493, compound

Conditions

Temperature
70 °C

Procedure

A suspension of 3-bromo-6-fluoroimidazo[1,2-b]pyridazine (2.16 g, 10 mmol) in hydrazine monohydrate (10 mL) was heated at 70° C. for 30 minutes. The mixture was cooled to room temperature, and the titled compound (1.78 g) was collected by filtration. 1H NMR (400 MHz, DMSO-d6) δ ppm 4.27 (br. s., 2H) 6.78 (d, J=9.60 Hz, 1H) 7.51 (s, 1H) 7.73 (dd, J=9.60, 1.52 Hz, 1H) 8.20 (br. s., 1H).

Workup

  1. temperatureThe mixture was cooled to room temperature
  2. filtrationthe titled compound (1.78 g) was collected by filtration

Sources & evidence

ORD record
ord-20bb5375a4d642ae939cb3c38b937a79
Source dataset
uspto-grants-2015_03
Patent number
US08969565B2

Reaction notes

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