Ethyl trifluoroacetate → HCID 86696495, compound

HRID 870788Notes

Reaction equation

HRID 870788 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[O:5][CH2:6][CH2:7][NH:8][CH2:9][CH2:10][NH2:11].[F:15][C:16]([F:23])([F:22])[C:17](OCC)=[O:18]>O1CCCC1>[Br:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[O:5][CH2:6][CH2:7][NH:8][CH2:9][CH2:10][NH:11][C:17](=[O:18])[C:16]([F:23])([F:22])[F:15]

Participants

4

Reactant 2

HCID 9794Ethyl trifluoroacetateHCID 2299525HCID 2299525, compound

Product 1

HCID 86696495HCID 86696495, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a stirred, 0° C., solution of N1-(2-(3-bromophenoxy)ethyl)ethane-1,2-diamine (4.7 g, 17.9 mmol) in anhydrous tetrahydrofuran (180 mL) was added ethyl trifluoroacetate [383-63-1] (2.1 mL, 17.9 mmol). The resultant solution was allowed to stir under N2 blanket for 15 minutes then evaporated to dryness to obtain N-{2-[2-(3-Bromo-phenoxy)-ethylamino]-ethyl}-2,2,2-trifluoro-acetamide as 6.3 g of yellow solid. LRMS (ESI) m/z 355.1/357.1 [(M+H)]+, calc'd for C12H14BrF3N2O2: 355.16.

Workup

  1. customthen evaporated to dryness

Sources & evidence

ORD record
ord-f0a30dd2cba942cf9d17c084b14579c0
Source dataset
uspto-grants-2015_03
Patent number
US08969565B2

Reaction notes

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