反应详情

To a solution of 1-(4-{4-cyano-3-[(3-morpholin-4-ylpropyl)amino]isothiazol-5-yl}phenyl)-3-(2-fluoro-5-methylphenyl)urea (5 mg, 0.011 mmol) in 0.8 mL DMSO at rt was added catalytic K2CO3, 1 drop 30% hydrogen peroxide and the reaction stirred at rt for 30 min. The reaction was added into a solution of dilute brine and the precipitant filtered and rinsed with water, then 20% EtOAc/hexane. The product was washed from the filter paper using 15% MeOH/CHCl3 and then evaporated to give the title compound as a white solid (5 mg, 85%).

1. filtrationthe precipitant filtered
2. washrinsed with water
3. washThe product was washed from the filter paper
4. customevaporated