反应详情

Cinacalcet base Compound of formula (I) (5.0 gm) was dissolved in diisopropylether (50 ml) and the pH of the solution was adjusted to 1-2 using concentrated hydrochloric acid at 25-30° C. The mass was stirred for 30 minutes, precipitated solid was filtered, washed with diisopropylether (10 ml) and dried under vacuum to yield 4.8 gm (86.48%) of Cinacalcet hydrochloride; HPLC purity 99.67%; Chiral purity: 99.92%.

1. customprecipitated solid
2. filtrationwas filtered
3. washwashed with diisopropylether (10 ml)
4. customdried under vacuum