Iodine → 1,2-Bis(trimethylsilyl)benzene

Temperature

70 °C

Magnesium (9.72 g, 400 mmol), hexamethylphosphoramide (HMPA) (80 mL, 460 mmol), 1,2-dichlorobenzene (14.76 g, 100 mmol), and a catalytic amount of I2 were combined in a 500 mL round bottomed flask and heated to 70° C. with stirring. Chlorotrimethylsilane was added dropwise to the solution at 70° C. The solution was stirred for an additional 30 minutes and then heated to 100° C. for 48 h. After cooling, the reaction mixture was poured over ice and NaHCO3. The Mg and precipitate were filtered off and the filtrate was extracted with ether (3×, 200 mL). The organic phase was washed with water (2×, 400 mL) and brine (1×, 400 mL) and dried with Na2SO4 and concentrated. The product was distilled under reduced pressure at 128-133° C. to yield a light yellow oil (12.0426 g, 54.13%). 1H NMR (300 MHz, CDCl3) δ 7.85 (dd, 2H, J=3.4 Hz, J=5.5 Hz, ArH), 7.49 (dd, 2H, J=3.4 Hz, J=5.5 Hz, ArH), 0.55 (s, 18H, CH3); 13C NMR (300 MHz, CDCl3) δ 145.98, 135.17, 127.76, 1.96

1. stirringThe solution was stirred for an additional 30 minutes
2. temperatureheated to 100° C. for 48 h
3. temperatureAfter cooling
4. filtrationThe Mg and precipitate were filtered off
5. extractionthe filtrate was extracted with ether (3×, 200 mL)
6. washThe organic phase was washed with water (2×, 400 mL) and brine (1×, 400 mL)
7. dry with materialdried with Na2SO4
8. concentrationconcentrated
9. distillationThe product was distilled under reduced pressure at 128-133° C.

ORD record

ord-664d4993e8a04590bb166a9024842222

Source dataset

uspto-grants-2015_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08969622B2