反应详情

温度

100 °C

To POCl3 (15 mL) was added 6,7-difluoro-4-hydroxyquinazoline (910 mg, 5 mmol) followed by triethylamine (700 uL, 5 mmol). The solution was then heated at 100° C. for 4 hours and concentrated in vacuo. The resulting sludge was triturated with EtOAc (2×100 mL), and the combined decanted org layers were flushed through a plug of silica gel to give 4-chloro-6,7-difluoroquinazoline (870 mg, 4.35 mmol, 87%). LC-MS (ESI) m/z 201 (M+H)+.

1. concentrationconcentrated in vacuo
2. customThe resulting sludge was triturated with EtOAc (2×100 mL)
3. customthe combined decanted org layers
4. customwere flushed through a plug of silica gel