Sodium ion → 4-(5-Chloro-2-(2-methoxypropan-2-yl)thiazolo[5,4-d]pyrimidin-7-yl)morpholine

HRID 87175Notes

Reaction equation

[CH3:23][I:24].[CH3:25][CH2:26][O:27][C:28](=[O:29])[CH3:30].[Cl:1][c:2]1[n:3][c:4]([N:15]2[CH2:16][CH2:17][O:18][CH2:19][CH2:20]2)[c:5]2[c:6]([n:7]1)[s:8][c:9]([C:11]([CH3:12])([CH3:13])[OH:14])[n:10]2.[H-:22].[Na+:21].[O:31]=[CH:32][N:33]([CH3:34])[CH3:35]>>[Cl:1][c:2]1[n:3][c:4]([N:15]2[CH2:16][CH2:17][O:18][CH2:19][CH2:20]2)[c:5]2[c:6]([n:7]1)[s:8][c:9]([C:11]([CH3:12])([CH3:13])[O:14][CH3:25])[n:10]2

Participants

Reactant 6

HCID 923Sodium ion

HCID 6228Dimethylformamide

HCID 6328Methyl iodide

HCID 8857Ethyl Acetate

HCID 166653Hydride

HCID 576854202-(5-Chloro-7-morpholinothiazolo[5,4-d]pyrimidin-2-yl)propan-2-ol

Product 1

HCID 866300674-(5-Chloro-2-(2-methoxypropan-2-yl)thiazolo[5,4-d]pyrimidin-7-yl)morpholine

Sources & evidence

ORD record: ord-912d64d3cfb54cb98cf20e0845791048
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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