Sodium Chloride → Phosphate

HRID 871803Notes

Reaction equation

HRID 871803 reaction equation
[CH:1]1[N:5]=[CH:4][N:3]([CH2:6][C:7]([P:13]([OH:16])([OH:15])=[O:14])([P:9]([OH:12])([OH:11])=[O:10])[OH:8])[CH:2]=1.[P:17]([O-:21])([O-:20])([O-:19])=[O:18].[Na+].[Na+].[Na+].O.O.[Cl-].[Ca+2].[Cl-].C1N=CN(CC(P(O)(O)=O)(P(O)(O)=O)O)C=1.P([O-])([O-])([O-])=O.[Cl-].[Ca+2].[Cl-].[Cl-].[Na+].[OH-].[Na+].C1N=CN(CC(P(O)(O)=O)(P(O)(O)=O)O)C=1.P([O-])([O-])([O-])=O.[Ca+2].P([O-])([O-])([O-])=O.[Ca+2].[Ca+2]>O>[CH:1]1[N:5]=[CH:4][N:3]([CH2:6][C:7]([P:9]([OH:12])([OH:11])=[O:10])([P:13]([OH:15])([OH:16])=[O:14])[OH:8])[CH:2]=1.[P:17]([O-:21])([O-:20])([O-:19])=[O:18]

Participants

11

Reactant 8

HCID 5234Sodium ChlorideHCID 14798Sodium HydroxideHCID 24243Trisodium PhosphateHCID 68740Zoledronic AcidHCID 5284359Calcium ChlorideHCID 6093260Calcium chloride, dihydrate2×HCID 131732543HCID 131732543, compound2×HCID 131732544HCID 131732544, compound

Product 2

HCID 1061PhosphateHCID 68740Zoledronic Acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent3×

Procedure

0.27 g (1 mM) zoledronic acid and 0.6 gm (5 mM) monobasic sodium phosphate (anhydrous) were dissolved in 10 mL water. 1.5 g calcium chloride dihydrate was dissolved in 5 mL water. The zoledronate-phosphate solution and calcium chloride solution were mixed at room temperature. 0.05 g calcium chloride dihydrate and 0.3 g sodium chloride were added to 20 mL water. Sodium hydroxide and zoledronate-calcium-phosphate solution were simultaneously added to keep the pH at 7.00 at room temperature until all the zoledronate-phosphate solution was added. The precipitate was collected by filtration and washed with water. The solid was dried in an oven at 120° C. 1.15 g of calcium complex salt of zoledronate with phosphate was thus obtained in a molecular ratio of 1:5.

Workup

  1. customat room temperature
  2. additionwas added
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with water
  5. customThe solid was dried in an oven at 120° C

Sources & evidence

ORD record
ord-f7d33dca255848ca8b9c4c0ecfef3c32
Source dataset
uspto-grants-2015_03
Patent number
US08974801B2

Reaction notes

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