Hydrochloric Acid → HCID 70926185, compound

HRID 871851Notes

Reaction equation

HRID 871851 reaction equation
[NH2:1][C:2]1[N:33]([CH2:34][CH3:35])[C:6]2[N:7]=[C:8]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([CH:18]4[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]4)=[CH:14][C:13]=3[O:31][CH3:32])[N:9]=[CH:10][C:5]=2[C:4](=[O:36])[C:3]=1[C:37](=[O:39])[NH2:38].[ClH:40].CCOCC>ClCCl.CO.O1CCOCC1>[ClH:40].[NH2:1][C:2]1[N:33]([CH2:34][CH3:35])[C:6]2[N:7]=[C:8]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([CH:18]4[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]4)=[CH:14][C:13]=3[O:31][CH3:32])[N:9]=[CH:10][C:5]=2[C:4](=[O:36])[C:3]=1[C:37]([NH2:38])=[O:39]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 86673134HCID 86673134, compound

Product 1

HCID 70926185HCID 70926185, compound

Reagents, catalysts & solvents 2

HCID 312751,4-DioxaneSolventHCID 21226129Dichloromethane methanolSolvent

Procedure

0.51 g (0.95 mmol) of the product prepared in step 4.4 is suspended in 10 mL of a dichloromethane/methanol mixture (v/v=8/2), and 3.55 mL (14.20 mmol) of a 4N solution of hydrogen chloride in dioxane are added. The mixture is stirred at room temperature overnight, and ether is added. The solid is drained by suction, rinsed with pentane and dried in an oven. 0.48 g the expected product is obtained in the form of a beige-coloured solid, which is used as obtained in the following step. Yield (dihydrochloride)=99.1°A. m.p.=117°C. M+H+=408.

Workup

  1. washrinsed with pentane
  2. customdried in an oven

Sources & evidence

ORD record
ord-df6ce069c1d1492984255422db189568
Source dataset
uspto-grants-2015_03
Patent number
US08975250B2

Reaction notes

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