Hydrochloric Acid → HCID 70925882, compound

HRID 871867Notes

Reaction equation

HRID 871867 reaction equation
[NH2:1][C:2]1[N:31]([CH2:32][CH3:33])[C:6]2[N:7]=[C:8]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([N:18]4[CH2:23][CH2:22][N:21]([CH:24]5[CH2:26][CH2:25]5)[CH2:20][CH2:19]4)=[CH:14][C:13]=3[O:27][CH:28]([F:30])[F:29])[N:9]=[CH:10][C:5]=2[C:4](=[O:34])[C:3]=1[C:35]([NH2:37])=[O:36].[ClH:38]>O1CCOCC1.CCOCC>[ClH:38].[NH2:1][C:2]1[N:31]([CH2:32][CH3:33])[C:6]2[N:7]=[C:8]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([N:18]4[CH2:19][CH2:20][N:21]([CH:24]5[CH2:26][CH2:25]5)[CH2:22][CH2:23]4)=[CH:14][C:13]=3[O:27][CH:28]([F:30])[F:29])[N:9]=[CH:10][C:5]=2[C:4](=[O:34])[C:3]=1[C:35]([NH2:37])=[O:36]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 53303871HCID 53303871, compound

Product 1

HCID 70925882HCID 70925882, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolvent2×HCID 312751,4-DioxaneSolvent

Procedure

0.11 g (0.21 mmol) of the product prepared in step 14.4 is suspended in 3 mL of anhydrous dioxane and 0.63 mL (0.63 mmol) of a 1M solution of hydrogen chloride in ether is added. The mixture is diluted with ether and the solid is then drained by suction, rinsed with pentane and dried in an oven. 0.11 g of the expected product is obtained in the form of a yellow powder. Yield (dihydrochloride)=87%. m.p.=204-206°C. M+H+=515.

Workup

  1. washrinsed with pentane
  2. customdried in an oven

Sources & evidence

ORD record
ord-92dfb3c71e1541f5bf593e1c45c82cea
Source dataset
uspto-grants-2015_03
Patent number
US08975250B2

Reaction notes

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