反应详情

1.39 g (5.0 mmol) of the product prepared in step 15.2 are dissolved in 25 mL of hot ethyl acetate. After cooling to room temperature, 25 mL of absolute ethanol and 0.057 g (0.25 mmol) of platinum (IV) oxide are successively added. The reaction mixture is placed under a hydrogen pressure of 2.75 bar for 2 hours, and is filtered through thin glass fibre paper. The filtrate is concentrated under vacuum and purified by chromatography on a column of silica, eluting with a cyclohexane/ethyl acetate gradient (from 70/30 to 55/45). 1.05 g of the expected product are obtained. Yield=85%.

1. customfor 2 hours
2. filtrationis filtered through thin glass fibre paper
3. concentrationThe filtrate is concentrated under vacuum
4. custompurified by chromatography on a column of silica
5. washeluting with a cyclohexane/ethyl acetate gradient (from 70/30 to 55/45)