Hydrochloric Acid → HCID 70926421, compound

HRID 871889Notes

Reaction equation

HRID 871889 reaction equation
[NH2:1][C:2]1[N:27]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:6]2[N:7]=[C:8]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([CH:18]4[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]4)=[CH:14][C:13]=3[O:25][CH3:26])[N:9]=[CH:10][C:5]=2[C:4](=[O:34])[C:3]=1[C:35]([NH2:37])=[O:36].[ClH:38]>C(Cl)Cl.CCOCC>[ClH:38].[NH2:1][C:2]1[N:27]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:6]2[N:7]=[C:8]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([CH:18]4[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]4)=[CH:14][C:13]=3[O:25][CH3:26])[N:9]=[CH:10][C:5]=2[C:4](=[O:34])[C:3]=1[C:35]([NH2:37])=[O:36]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67344591HCID 67344591, compound

Product 1

HCID 70926421HCID 70926421, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolvent2×HCID 6344DichloromethaneSolvent

Procedure

A solution of 0.065 g (0.13 mmol) of the product prepared in step 23.1 in 3 mL of CH2Cl2 is cooled on an ice bath, and 0.39 mL (0.39 mmol) of a 1M solution of hydrogen chloride in ether is added. The mixture is stirred for 10 minutes at room temperature and then poured into ether. The solid is drained by suction, rinsed with pentane and dried in an oven under vacuum. 0.059 g of the expected compound is obtained. Yield (dihydrochloride)=80%. m.p.=256°C. (decomposition). M+H+=500

Workup

  1. washrinsed with pentane
  2. customdried in an oven under vacuum

Sources & evidence

ORD record
ord-d8c2102d4e0340828b5fd27cc247028d
Source dataset
uspto-grants-2015_03
Patent number
US08975250B2

Reaction notes

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