Hydrochloric Acid → HCID 70926017, compound

HRID 871892Notes

Reaction equation

HRID 871892 reaction equation
[NH2:1][C:2]1[N:27]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:6]2[N:7]=[C:8]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][N:20]4[CH2:24][CH2:23][CH2:22][CH2:21]4)=[CH:14][C:13]=3[O:25][CH3:26])[N:9]=[CH:10][C:5]=2[C:4](=[O:34])[C:3]=1[C:35]([NH2:37])=[O:36].[ClH:38]>CO.CCOCC>[ClH:38].[NH2:1][C:2]1[N:27]([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[C:6]2[N:7]=[C:8]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][N:20]4[CH2:21][CH2:22][CH2:23][CH2:24]4)=[CH:14][C:13]=3[O:25][CH3:26])[N:9]=[CH:10][C:5]=2[C:4](=[O:34])[C:3]=1[C:35]([NH2:37])=[O:36]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67325378HCID 67325378, compound

Product 1

HCID 70926017HCID 70926017, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent2×

Procedure

A solution of 0.07 g (0.14 mmol) of the product prepared in step 24.4 in 3 mL of methanol is cooled on an ice bath, and 0.42 mL (0.42 mmol) of a 1M solution of hydrogen chloride in ether is added. The mixture is stirred for 10 minutes at room temperature and ether is then added. The solid is drained by suction, rinsed with pentane and dried in an oven under vacuum. 0.075 g of the expected compound is obtained. Yield (dihydrochloride)=93%.

Workup

  1. washrinsed with pentane
  2. customdried in an oven under vacuum

Sources & evidence

ORD record
ord-ce858f7186b04298825110ae4900db5f
Source dataset
uspto-grants-2015_03
Patent number
US08975250B2

Reaction notes

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