反应详情

温度

0 °C

To a solution of 4-cyano-piperidine-1-carboxylic acid tert-butyl ester (4.52 g, 20 mmol) in THF (50 mL) was added LHMDS in THF (24 mL, 24 mmol) at 0° C. After stirring at 0° C. for 1 hour, MeI (5.7 g) was added. The reaction mixture was kept at 0° C. for 2 hours, then partitioned between EtOAc and H2O. After concentration in vacuo, the residue was purified by silica column chromatography with EtOAc/hexanes to give the desired product.

1. waitThe reaction mixture was kept at 0° C. for 2 hours
2. custompartitioned between EtOAc and H2O
3. concentrationAfter concentration in vacuo
4. customthe residue was purified by silica column chromatography with EtOAc/hexanes