Methylamine → HCID 66665891, compound

HRID 872311Notes

Reaction equation

HRID 872311 reaction equation
CO[C:3]([C:5]1[CH:6]=[CH:7][C:8]2[N:9]([C:11]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([C:20]4([NH:24][C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:23][CH2:22][CH2:21]4)=[CH:16][CH:15]=3)[N:13]=2)[CH:10]=1)=[O:4].[CH3:38][NH2:39]>CO>[C:28]([O:27][C:25](=[O:26])[NH:24][C:20]1([C:17]2[CH:18]=[CH:19][C:14]([C:12]3[N:13]=[C:8]4[CH:7]=[CH:6][C:5]([C:3](=[O:4])[NH:39][CH3:38])=[CH:10][N:9]4[C:11]=3[C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)=[CH:15][CH:16]=2)[CH2:23][CH2:22][CH2:21]1)([CH3:31])([CH3:29])[CH3:30]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 66665070HCID 66665070, compound

Product 1

HCID 66665891HCID 66665891, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-3-phenyl-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester (100 mg) and a solution of methylamine in methanol (2M, 1.4 mL) was heated at 100° C. under microwave irradiation for 90 minutes followed by a further 90 minutes. On cooling, the reaction mixture was concentrated in vacuo to give the title compound which was used without further purification in the next step.

Workup

  1. temperatureOn cooling
  2. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-d2b4ca6c293b44c9b00d860dc199ba66
Source dataset
uspto-grants-2015_03
Patent number
US08975265B2

Reaction notes

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