反应详情

温度

0 °C

The crude product from Step 2 (240 mg) was dissolved in DCM/MeOH (1.2 mL/0.76 mL), cooled to 0° C. and treated with HCl (4 M soln in dioxane, 0.94 mL). The reaction was warmed to rt and stirred for 2 hours. The reaction was poured onto ice and extracted with DCM (3×). The organic phase was washed with brine, dried and concentrated in vacuo to give the crude title compound.

1. temperatureThe reaction was warmed to rt
2. additionThe reaction was poured onto ice
3. extractionextracted with DCM (3×)
4. washThe organic phase was washed with brine
5. customdried
6. concentrationconcentrated in vacuo