Triethylamine → HCID 67169035, compound

HRID 872922Notes

Reaction equation

HRID 872922 reaction equation
[CH3:1][CH2:2][O:3][C:4](/[C:6](/Cl)=[N:7]\[OH:8])=[O:5].[CH2:10]([O:14][CH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][O:16]1)[CH2:11][C:12]#[CH:13].C(N(CC)CC)C>C(OCC)C>[O:16]1[CH2:17][CH2:18][CH2:19][CH2:20][CH:15]1[O:14][CH2:10][CH2:11][C:12]1[O:8][N:7]=[C:6]([C:4]([O:3][CH2:2][CH3:1])=[O:5])[CH:13]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 1424402-(3-Butynyloxy)tetrahydro-2H-pyranHCID 6399471Ethyl 2-chloro-2-(hydroxyimino)acetate

Product 1

HCID 67169035HCID 67169035, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

Ethyl chlorooximidoacetate (1 g, 6.60 mmol) and 2-(but-3-ynyloxy)tetrahydro-2H-pyran (3.05 g, 19.80 mmol) were dissolved in diethyl ether (20 ml). Triethylamine (0.668 g, 6.60 mmol) was diluted with diethyl ether (10 ml) and added dropwise into previous mixture. After addition the reaction mixture was extracted with water and the organic layer was dried with Na2SO4, filtered and evaporated. LC-MS: [M+1]=172.17.

Workup

  1. additionadded dropwise into previous mixture
  2. additionAfter addition the reaction mixture
  3. extractionwas extracted with water
  4. dry with materialthe organic layer was dried with Na2SO4
  5. filtrationfiltered
  6. customevaporated

Sources & evidence

ORD record
ord-36583926c8d44fcd9d167d7913620ef1
Source dataset
uspto-grants-2015_03
Patent number
US08975254B2

Reaction notes

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