Sodium hydride → HCID 86724199, compound

HRID 873181Notes

Reaction equation

HRID 873181 reaction equation
[H-].[Na+].[OH:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([O:13][C:14]2[CH:15]=[N:16][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:18][CH:19]=2)=[C:9]([CH:12]=1)[C:10]#[N:11].Cl[C:25]1[CH:26]=[C:27]2[N:34]([CH3:35])[CH2:33][CH2:32][N:28]2[C:29](=[O:31])[N:30]=1>C1COCC1>[CH3:35][N:34]1[C:27]2[N:28]([C:29](=[O:31])[N:30]=[C:25]([O:3][CH2:4][C:5]3[CH:6]=[CH:7][C:8]([O:13][C:14]4[CH:15]=[N:16][C:17]([C:20]([F:23])([F:21])[F:22])=[CH:18][CH:19]=4)=[C:9]([CH:12]=3)[C:10]#[N:11])[CH:26]=2)[CH2:32][CH2:33]1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 66825600HCID 66825600, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 86724199HCID 86724199, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared in a manner similar to that described for E1 using sodium hydride (6.52 mg, 0.272 mmol), 5-(hydroxymethyl)-2-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzonitrile (80 mg, 0.272 mmol) in THF (8 mL) and 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (50.5 mg, 0.272 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-5832e595d1c84dd5921e376383bb6bc0
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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