Sodium hydride → HCID 71241180, compound

HRID 873184Notes

Reaction equation

HRID 873184 reaction equation
[H-].[Na+].[F:3][C:4]1[CH:5]=[C:6]([CH:20]=[CH:21][C:22]=1[F:23])[O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][OH:15])=[CH:10][C:9]=1[C:16]([F:19])([F:18])[F:17].Cl[C:25]1[CH:26]=[C:27]2[N:34]([CH3:35])[CH2:33][CH2:32][N:28]2[C:29](=[O:31])[N:30]=1>C1COCC1>[F:3][C:4]1[CH:5]=[C:6]([CH:20]=[CH:21][C:22]=1[F:23])[O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][O:15][C:25]2[CH:26]=[C:27]3[N:34]([CH3:35])[CH2:33][CH2:32][N:28]3[C:29](=[O:31])[N:30]=2)=[CH:10][C:9]=1[C:16]([F:17])([F:18])[F:19]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 71240983HCID 71240983, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 71241180HCID 71241180, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared in a manner similar to that described for E1 using sodium hydride (15.78 mg, 0.394 mmol), (4-(3,4-difluorophenoxy)-3-(trifluoromethyl)phenyl)methanol (80 mg, 0.263 mmol) in THF (8 mL) and 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (48.8 mg, 0.263 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-8b53061b6edc4c1093b19b8c8c6823e3
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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