Sodium hydride → HCID 71243771, compound

HRID 873189Notes

Reaction equation

HRID 873189 reaction equation
[H-].[Na+].[F:3][C:4]1[CH:5]=[C:6]([CH2:22][OH:23])[CH:7]=[CH:8][C:9]=1[O:10][C:11]1[CH:16]=[CH:15][C:14]([F:17])=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:12]=1.Cl[C:25]1[CH:26]=[C:27]2[N:34](C(OC(C)(C)C)=O)[CH2:33][CH2:32][N:28]2[C:29](=[O:31])[N:30]=1>>[F:3][C:4]1[CH:5]=[C:6]([CH:7]=[CH:8][C:9]=1[O:10][C:11]1[CH:16]=[CH:15][C:14]([F:17])=[C:13]([C:18]([F:19])([F:20])[F:21])[CH:12]=1)[CH2:22][O:23][C:25]1[CH:26]=[C:27]2[NH:34][CH2:33][CH2:32][N:28]2[C:29](=[O:31])[N:30]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 66825660HCID 66825660, compoundHCID 71743561Tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-C]pyrimidine-1(5H)-carboxylate

Product 1

HCID 71243771HCID 71243771, compound

Procedure

Prepared in a manner similar to that described for E65 using NaH (11.04 mg, 0.276 mmol), (3-fluoro-4-(4-fluoro-3-(trifluoromethyl)phenoxy)-phenyl)methanol (56.0 mg, 0.184 mmol) and tertbutyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate (50 mg, 0.18 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-3aea0808ede0437db2a9f3ecedbb427c
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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