Sodium hydride → HCID 86724201, compound

HRID 873192Notes

Reaction equation

HRID 873192 reaction equation
Cl[C:2]1[CH:3]=[C:4]2[N:11]([CH3:12])[CH2:10][CH2:9][N:5]2[C:6](=[O:8])[N:7]=1.[H-].[Na+].[Br:15][C:16]1[CH:32]=[CH:31][C:19]([O:20][C:21]2[CH:28]=[CH:27][C:26]([CH2:29][OH:30])=[CH:25][C:22]=2[C:23]#[N:24])=[CH:18][C:17]=1[F:33]>CN(C=O)C>[Br:15][C:16]1[CH:32]=[CH:31][C:19]([O:20][C:21]2[CH:28]=[CH:27][C:26]([CH2:29][O:30][C:2]3[CH:3]=[C:4]4[N:11]([CH3:12])[CH2:10][CH2:9][N:5]4[C:6](=[O:8])[N:7]=3)=[CH:25][C:22]=2[C:23]#[N:24])=[CH:18][C:17]=1[F:33]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 71240355HCID 71240355, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 86724201HCID 86724201, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared in a manner similar to that described for E1 using 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (200 mg, 1.078 mmol), sodium hydride (86 mg, 2.155 mmol) and 2-(4-bromo-3-fluorophenoxy)-5-(hydroxymethyl)benzonitrile (346 mg, 1.074 mmol) in DMF (5 mL).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-c19075a379a542c88f193c05eb1e090c
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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