Sodium hydride → HCID 71241079, compound

HRID 873194Notes

Reaction equation

HRID 873194 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([O:9][C:10]2[CH:17]=[CH:16][C:15]([CH2:18][OH:19])=[CH:14][C:11]=2[C:12]#[N:13])[CH:5]=[N:6][C:7]=1[F:8].[H-].[Na+].Cl[C:23]1[CH:24]=[C:25]2[N:32]([CH3:33])[CH2:31][CH2:30][N:26]2[C:27](=[O:29])[N:28]=1>C1COCC1>[F:1][C:2]1[CH:3]=[C:4]([O:9][C:10]2[CH:17]=[CH:16][C:15]([CH2:18][O:19][C:23]3[CH:24]=[C:25]4[N:32]([CH3:33])[CH2:31][CH2:30][N:26]4[C:27](=[O:29])[N:28]=3)=[CH:14][C:11]=2[C:12]#[N:13])[CH:5]=[N:6][C:7]=1[F:8]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 71240182HCID 71240182, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 71241079HCID 71241079, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared in a manner similar to that described for E1 using 2-((5,6-difluoropyridin-3-yl)oxy)-5-(hydroxymethyl)benzonitrile (131 mg, 0.5 mmol) in THF (4 mL), NaH (30.0 mg, 0.750 mmol) and 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (93 mg, 0.500 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-b82a3ba7c0594eddaa45db78bfd2110d
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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