Sodium hydride → HCID 86724203, compound

HRID 873200Notes

Reaction equation

HRID 873200 reaction equation
Cl[C:2]1[CH:3]=[C:4]2[N:11]([CH3:12])[CH2:10][CH2:9][N:5]2[C:6](=[O:8])[N:7]=1.[H-].[Na+].[F:15][C:16]1[CH:17]=[C:18]([CH2:35][OH:36])[CH:19]=[C:20]([F:34])[C:21]=1[O:22][C:23]1[CH:28]=[CH:27][C:26]([F:29])=[C:25]([C:30]([F:33])([F:32])[F:31])[CH:24]=1>CN(C=O)C>[F:15][C:16]1[CH:17]=[C:18]([CH:19]=[C:20]([F:34])[C:21]=1[O:22][C:23]1[CH:28]=[CH:27][C:26]([F:29])=[C:25]([C:30]([F:33])([F:31])[F:32])[CH:24]=1)[CH2:35][O:36][C:2]1[CH:3]=[C:4]2[N:11]([CH3:12])[CH2:10][CH2:9][N:5]2[C:6](=[O:8])[N:7]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-oneHCID 86676394HCID 86676394, compound

Product 1

HCID 86724203HCID 86724203, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared in a manner similar to that described for E1 using 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (30 mg, 0.162 mmol), sodium hydride (12.93 mg, 0.323 mmol) and (3,5-difluoro-4-(4-fluoro-3-(trifluoromethyl)pheno-xy)phenyl)m-ethanol (52.1 mg, 0.162 mmol) in DMF (1.5 ml).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-72f849bcfe8549cca819ca80bd825112
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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