Sodium hydride → HCID 71243701, compound

HRID 873201Notes

Reaction equation

HRID 873201 reaction equation
Cl[C:2]1[CH:3]=[C:4]2[N:11]([CH3:12])[CH2:10][CH2:9][N:5]2[C:6](=[O:8])[N:7]=1.[H-].[Na+].[Cl:15][C:16]1[CH:17]=[C:18]([CH:30]=[CH:31][CH:32]=1)[O:19][C:20]1[C:25]([F:26])=[CH:24][C:23]([CH2:27][OH:28])=[CH:22][C:21]=1[F:29]>CN(C=O)C>[Cl:15][C:16]1[CH:17]=[C:18]([CH:30]=[CH:31][CH:32]=1)[O:19][C:20]1[C:25]([F:26])=[CH:24][C:23]([CH2:27][O:28][C:2]2[CH:3]=[C:4]3[N:11]([CH3:12])[CH2:10][CH2:9][N:5]3[C:6](=[O:8])[N:7]=2)=[CH:22][C:21]=1[F:29]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 63077582HCID 63077582, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 71243701HCID 71243701, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared in a manner similar to that described for E1 using 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (30 mg, 0.162 mmol), sodium hydride (12.93 mg, 0.323 mmol) and (4-(3-chlorophenoxy)-3,5-difluorophenyl)methanol (43.7 mg, 0.162 mmol) in DMF (1.5 mL).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-ea47f921e01040a8b61e39a944636b62
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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