Sodium hydride → HCID 86724204, compound

HRID 873204Notes

Reaction equation

HRID 873204 reaction equation
Cl[C:2]1[CH:3]=[C:4]2[N:11]([CH3:12])[CH2:10][CH2:9][N:5]2[C:6](=[O:8])[N:7]=1.[H-].[Na+].[Cl:15][C:16]1[CH:32]=[CH:31][C:19]([O:20][C:21]2[C:26]([F:27])=[CH:25][C:24]([CH2:28][OH:29])=[CH:23][C:22]=2[F:30])=[CH:18][C:17]=1[F:33]>CN(C=O)C>[Cl:15][C:16]1[CH:32]=[CH:31][C:19]([O:20][C:21]2[C:26]([F:27])=[CH:25][C:24]([CH2:28][O:29][C:2]3[CH:3]=[C:4]4[N:11]([CH3:12])[CH2:10][CH2:9][N:5]4[C:6](=[O:8])[N:7]=3)=[CH:23][C:22]=2[F:30])=[CH:18][C:17]=1[F:33]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 71236578HCID 71236578, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 86724204HCID 86724204, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared in a manner similar to that described for E1 using 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (50 mg, 0.269 mmol), sodium hydride (21.55 mg, 0.539 mmol) and (4-(4-chloro-3-fluorophenoxy)-3,5-difluorophenyl)methanol (78 mg, 0.269 mmol) in DMF (2 mL).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-a4f23bba3b0449bb86a3990bd477f96e
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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