Sodium hydride → HCID 86724206, compound

HRID 873210Notes

Reaction equation

HRID 873210 reaction equation
[H-].[Na+].[OH:3][CH2:4][C:5]1[CH:23]=[CH:22][C:8]([O:9][C:10]2[CH:11]=[C:12]([CH:15]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:17]=2)[C:13]#[N:14])=[C:7]([C:24]([F:27])([F:26])[F:25])[CH:6]=1.Cl[C:29]1[CH:30]=[C:31]2[N:38]([CH3:39])[CH2:37][CH2:36][N:32]2[C:33](=[O:35])[N:34]=1>C1COCC1>[CH3:39][N:38]1[C:31]2[N:32]([C:33](=[O:35])[N:34]=[C:29]([O:3][CH2:4][C:5]3[CH:23]=[CH:22][C:8]([O:9][C:10]4[CH:11]=[C:12]([CH:15]=[C:16]([C:18]([F:19])([F:20])[F:21])[CH:17]=4)[C:13]#[N:14])=[C:7]([C:24]([F:25])([F:26])[F:27])[CH:6]=3)[CH:30]=2)[CH2:36][CH2:37]1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-oneHCID 86724207HCID 86724207, compound

Product 1

HCID 86724206HCID 86724206, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared in a manner similar to that described for E1 using sodium hydride (9.37 mg, 0.234 mmol), 3-(4-(hydroxymethyl)-2-(trifluoromethyl)phenoxy)-5-(trifluoromethyl)benzonitrile (56.4 mg, 0.156 mmol) in THF (8 mL) and 7-chloro-1-methyl-2,3-dihydroi-midazo[1,2-c]pyrimidin-5(1H)-one (29 mg, 0.156 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-fd69c53c70964f6fb4960851bca4d734
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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