tert-butyl 7-((4-(3,4-dichlorophenoxy)-3-fluorobenzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate → 7-((4-(3,4-dichlorophenoxy)-3-fluorobenzyl)oxy)-2,3-dihydroimidazo[1,2-c]pyrimi-din-5(1H)-one

HRID 873211Notes

Reaction equation

HRID 873211 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:32]=[CH:33][C:34]=1[Cl:35])[O:5][C:6]1[CH:30]=[CH:29][C:9]([CH2:10][O:11][C:12]2[CH:13]=[C:14]3[N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19][N:15]3[C:16](=[O:18])[N:17]=2)=[CH:8][C:7]=1[F:31]>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:32]=[CH:33][C:34]=1[Cl:35])[O:5][C:6]1[CH:30]=[CH:29][C:9]([CH2:10][O:11][C:12]2[CH:13]=[C:14]3[NH:21][CH2:20][CH2:19][N:15]3[C:16](=[O:18])[N:17]=2)=[CH:8][C:7]=1[F:31]

Participants

3

Reactant 1

HCID 71243763tert-butyl 7-((4-(3,4-dichlorophenoxy)-3-fluorobenzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

Product 1

HCID 867242087-((4-(3,4-dichlorophenoxy)-3-fluorobenzyl)oxy)-2,3-dihydroimidazo[1,2-c]pyrimi-din-5(1H)-one

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared in a manner similar to that described for E71 using tert-butyl 7-((4-(3,4-dichlorophenoxy)-3-fluorobenzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate (30 mg, 0.057 mmol) in DMF (2 mL) and silica gel (150 mg).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-ad2917a9c90c4734ba7b49d1a8ad88cc
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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