Sodium hydride → HCID 86724211, compound

HRID 873215Notes

Reaction equation

HRID 873215 reaction equation
Cl[C:2]1[CH:3]=[C:4]2[N:11]([CH3:12])[CH2:10][CH2:9][N:5]2[C:6](=[O:8])[N:7]=1.[H-].[Na+].[F:15][C:16]1[CH:30]=[C:29]([CH2:31][OH:32])[CH:28]=[C:27]([F:33])[C:17]=1[O:18][C:19]1[CH:20]=[C:21]([CH:24]=[CH:25][CH:26]=1)[C:22]#[N:23]>CN(C=O)C>[F:15][C:16]1[CH:30]=[C:29]([CH2:31][O:32][C:2]2[CH:3]=[C:4]3[N:11]([CH3:12])[CH2:10][CH2:9][N:5]3[C:6](=[O:8])[N:7]=2)[CH:28]=[C:27]([F:33])[C:17]=1[O:18][C:19]1[CH:20]=[C:21]([CH:24]=[CH:25][CH:26]=1)[C:22]#[N:23]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 63075498HCID 63075498, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 86724211HCID 86724211, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared in a manner similar to that described for E1 using 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (60 mg, 0.323 mmol), sodium hydride (25.9 mg, 0.647 mmol) and 3-(2,6-difluoro-4-(hydroxymethyl)phenoxy)benzonitrile (84 mg, 0.323 mmol) in DMF (2 mL).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-0ceb415bb77f4e7d8e36321f4b407735
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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