Sodium hydride → HCID 86724214, compound

HRID 873217Notes

Reaction equation

HRID 873217 reaction equation
Cl[C:2]1[CH:3]=[C:4]2[N:11]([CH3:12])[CH2:10][CH2:9][N:5]2[C:6](=[O:8])[N:7]=1.[H-].[Na+].[C:15]([C:17]1[CH:31]=[C:30]([CH2:32][OH:33])[CH:29]=[CH:28][C:18]=1[O:19][C:20]1[CH:21]=[CH:22][C:23]([C:26]#[N:27])=[N:24][CH:25]=1)#[N:16]>CN(C=O)C>[C:15]([C:17]1[CH:31]=[C:30]([CH2:32][O:33][C:2]2[CH:3]=[C:4]3[N:11]([CH3:12])[CH2:10][CH2:9][N:5]3[C:6](=[O:8])[N:7]=2)[CH:29]=[CH:28][C:18]=1[O:19][C:20]1[CH:21]=[CH:22][C:23]([C:26]#[N:27])=[N:24][CH:25]=1)#[N:16]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 71239972HCID 71239972, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 86724214HCID 86724214, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared in a manner similar to that described for E1 using 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (50 mg, 0.269 mmol), sodium hydride (21.55 mg, 0.539 mmol) and 5-(2-cyano-4-(hydroxymethyl)phenoxy)picolinonitrile (67.7 mg, 0.269 mmol) in DMF (2 mL).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-1713c5caabcb4426abf8a87d35abf270
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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