Sodium hydride → HCID 86724217, compound

HRID 873220Notes

Reaction equation

HRID 873220 reaction equation
Cl[C:2]1[CH:3]=[C:4]2[N:11]([CH3:12])[CH2:10][CH2:9][N:5]2[C:6](=[O:8])[N:7]=1.[H-].[Na+].[F:15][C:16]1[CH:17]=[C:18]([CH:30]=[C:31]([F:33])[CH:32]=1)[O:19][C:20]1[CH:27]=[CH:26][C:25]([CH2:28][OH:29])=[CH:24][C:21]=1[C:22]#[N:23]>CN(C=O)C>[F:15][C:16]1[CH:17]=[C:18]([CH:30]=[C:31]([F:33])[CH:32]=1)[O:19][C:20]1[CH:27]=[CH:26][C:25]([CH2:28][O:29][C:2]2[CH:3]=[C:4]3[N:11]([CH3:12])[CH2:10][CH2:9][N:5]3[C:6](=[O:8])[N:7]=2)=[CH:24][C:21]=1[C:22]#[N:23]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 71240315HCID 71240315, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 86724217HCID 86724217, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared in a manner similar to that described for E1 using 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (50 mg, 0.269 mmol), sodium hydride (21.55 mg, 0.539 mmol) and 2-(3,5-difluorophenoxy)-5-(hydroxymethyl)benzonitrile (70.4 mg, 0.269 mmol) in DMF (2 mL).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-b14722c0371d4ecba586e616704faf14
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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