Trifluoroacetic acid → HCID 71243830, compound

HRID 873223Notes

Reaction equation

HRID 873223 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:25]=[CH:26][C:27]=1[O:28][C:29]1[CH:30]=[N:31][C:32]([F:36])=[C:33]([F:35])[CH:34]=1)[CH2:6][O:7][C:8]1[CH:9]=[C:10]2[N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15][N:11]2[C:12](=[O:14])[N:13]=1)#[N:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:35][C:33]1[CH:34]=[C:29]([O:28][C:27]2[CH:26]=[CH:25][C:5]([CH2:6][O:7][C:8]3[CH:9]=[C:10]4[NH:17][CH2:16][CH2:15][N:11]4[C:12](=[O:14])[N:13]=3)=[CH:4][C:3]=2[C:1]#[N:2])[CH:30]=[N:31][C:32]=1[F:36]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 71241024HCID 71241024, compound

Product 1

HCID 71243830HCID 71243830, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared in a manner similar to that described for E60 using tert-butyl 7-((3-cyano-4-((5,6-difluoropyridin-3-yl)oxy)benzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate (14 mg, 0.028 mmol) in DCM (4 mL) and TFA (0.5 mL, 6.49 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-0fbec35efed440228d1f398a30297eef
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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