tert-butyl 7-((3-fluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-5-oxo-2,3 dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate → 7-((3-fluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

HRID 873225Notes

Reaction equation

HRID 873225 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:24]=[CH:25][C:26]=1[O:27][C:28]1[CH:33]=[CH:32][N:31]=[C:30]([C:34]([F:37])([F:36])[F:35])[CH:29]=1)[CH2:5][O:6][C:7]1[CH:8]=[C:9]2[N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14][N:10]2[C:11](=[O:13])[N:12]=1>CN(C=O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:24]=[CH:25][C:26]=1[O:27][C:28]1[CH:33]=[CH:32][N:31]=[C:30]([C:34]([F:37])([F:35])[F:36])[CH:29]=1)[CH2:5][O:6][C:7]1[CH:8]=[C:9]2[NH:16][CH2:15][CH2:14][N:10]2[C:11](=[O:13])[N:12]=1

Participants

3

Reactant 1

HCID 71243818tert-butyl 7-((3-fluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-5-oxo-2,3 dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

Product 1

HCID 712410267-((3-fluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared in a manner similar to that described for E71 using tert-butyl 7-((3-fluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyri-midine-1(5H)-carboxylate (50 mg, 0.096 mmol) in DMF (2 mL) and silica gel.

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-63f36dbdfb574973bba882484233a42b
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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