Sodium hydride → HCID 71241160, compound

HRID 873233Notes

Reaction equation

HRID 873233 reaction equation
[H-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([O:10][C:11]2[CH:18]=[CH:17][C:16]([CH2:19][OH:20])=[CH:15][C:12]=2[C:13]#[N:14])[CH:7]=[N:8][CH:9]=1.Cl[C:22]1[CH:23]=[C:24]2[N:31]([CH3:32])[CH2:30][CH2:29][N:25]2[C:26](=[O:28])[N:27]=1>C1COCC1>[Cl:3][C:4]1[CH:5]=[C:6]([O:10][C:11]2[CH:18]=[CH:17][C:16]([CH2:19][O:20][C:22]3[CH:23]=[C:24]4[N:31]([CH3:32])[CH2:30][CH2:29][N:25]4[C:26](=[O:28])[N:27]=3)=[CH:15][C:12]=2[C:13]#[N:14])[CH:7]=[N:8][CH:9]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 66825586HCID 66825586, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 71241160HCID 71241160, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared in a manner similar to that described for E1 using sodium hydride (5.52 mg, 0.230 mmol) in THF (5 mL), 2-((5-chloropyridin-3-yl)oxy)-5-(hydroxymethyl)ben-zonitrile (30 mg, 0.115 mmol) and 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidi-n-5(1H)-one (21.4 mg, 0.115 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-4c2808fd828c4c76a6f170d2d2c35967
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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