Sodium hydride → HCID 71241156, compound

HRID 873234Notes

Reaction equation

HRID 873234 reaction equation
[H-].[Na+].[OH:3][CH2:4][C:5]1[CH:6]=[N:7][C:8]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=2)=[C:9]([CH:12]=1)[C:10]#[N:11].Cl[C:25]1[CH:26]=[C:27]2[N:34]([CH3:35])[CH2:33][CH2:32][N:28]2[C:29](=[O:31])[N:30]=1>C1COCC1>[CH3:35][N:34]1[C:27]2[N:28]([C:29](=[O:31])[N:30]=[C:25]([O:3][CH2:4][C:5]3[CH:6]=[N:7][C:8]([O:13][C:14]4[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:21])[F:22])[CH:15]=4)=[C:9]([CH:12]=3)[C:10]#[N:11])[CH:26]=2)[CH2:32][CH2:33]1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 71239622HCID 71239622, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 71241156HCID 71241156, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared in a manner similar to that described for E1 using sodium hydride (6.46 mg, 0.162 mmol), 5-(hydroxymethyl)-2-(3-(trifluoromethyl)phenoxy)nicotinonitrile (31.7 mg, 0.108 mmol) in THF (8 mL) and 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (20 mg, 0.11 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-16d18a84405548ac91e9d047c82e3767
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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