Sodium hydride → HCID 71243738, compound

HRID 873235Notes

Reaction equation

HRID 873235 reaction equation
[H-].[Na+].[F:3][C:4]1[CH:11]=[C:10]([O:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][OH:20])=[CH:15][C:14]=2[F:21])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7].Cl[C:23]1[CH:24]=[C:25]2[N:32]([CH3:33])[CH2:31][CH2:30][N:26]2[C:27](=[O:29])[N:28]=1>C1COCC1>[F:3][C:4]1[CH:11]=[C:10]([O:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][O:20][C:23]3[CH:24]=[C:25]4[N:32]([CH3:33])[CH2:31][CH2:30][N:26]4[C:27](=[O:29])[N:28]=3)=[CH:15][C:14]=2[F:21])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 71240173HCID 71240173, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 71243738HCID 71243738, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared in a manner similar to that described for E1 using sodium hydride (5.51 mg, 0.230 mmol) in THF (5 mL), 2-fluoro-4-(2-fluoro-4-(hydroxymethyl)phenoxy)benzonitrile (30 mg, 0.115 mmol) and 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (21.3 mg, 0.115 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-87529fc291044920ba837e78478b05cb
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

Loading…