Sodium hydride → HCID 86724218, compound

HRID 873237Notes

Reaction equation

HRID 873237 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:21][OH:22])[CH:5]=[C:6]([F:20])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[C:11]([F:19])[CH:10]=1.[H-].[Na+].Cl[C:26]1[CH:27]=[C:28]2[N:35]([CH3:36])[CH2:34][CH2:33][N:29]2[C:30](=[O:32])[N:31]=1>CN(C=O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[C:6]([F:20])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:17])([F:18])[F:16])=[C:11]([F:19])[CH:10]=1)[CH2:21][O:22][C:26]1[CH:27]=[C:28]2[N:35]([CH3:36])[CH2:34][CH2:33][N:29]2[C:30](=[O:32])[N:31]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-oneHCID 86724219HCID 86724219, compound

Product 1

HCID 86724218HCID 86724218, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared in a manner similar to that described for E1 using (3,5-difluoro-4-(3-fluoro-4-(trifluoromethyl)phenoxy)phenyl)methanol (122 mg, 0.377 mmol) in DMF (4 mL), sodium hydride (45.3 mg, 1.131 mmol) and 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (70 mg, 0.377 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-35fadc1d65244252b69d012eb97567ba
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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