Sodium hydride → HCID 71241184, compound

HRID 873241Notes

Reaction equation

HRID 873241 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:4]=[C:5]([O:9][C:10]2[CH:15]=[CH:14][C:13]([CH2:16][OH:17])=[CH:12][CH:11]=2)[CH:6]=[N:7][CH:8]=1.[H-].[Na+].Cl[C:23]1[CH:24]=[C:25]2[N:32]([CH3:33])[CH2:31][CH2:30][N:26]2[C:27](=[O:29])[N:28]=1>CN(C=O)C>[CH3:33][N:32]1[C:25]2[N:26]([C:27](=[O:29])[N:28]=[C:23]([O:17][CH2:16][C:13]3[CH:12]=[CH:11][C:10]([O:9][C:5]4[CH:6]=[N:7][CH:8]=[C:3]([C:2]([F:18])([F:1])[F:19])[CH:4]=4)=[CH:15][CH:14]=3)[CH:24]=2)[CH2:30][CH2:31]1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 71240254HCID 71240254, compoundHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 71241184HCID 71241184, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared in a manner similar to that described for E1 using (4-((5-(trifluoromethyl)pyridin-3-yl)oxy)phenyl)methanol (250 mg, 0.929 mmol) in DMF (5 mL), sodium hydride (66.9 mg, 2.79 mmol) and 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (172 mg, 0.929 mmol).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-05a37087a9db48bdb4f55e01103dc14b
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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