HCID 131732559, compound → HCID 87286061, compound

HRID 873245Notes

Reaction equation

HRID 873245 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][CH:9]=[C:10]([C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)[C:11]([O:13]CC)=O)[CH:5]=[CH:4][N:3]=1>C1(OC2C=CC=CC=2)C=CC=CC=1>[Cl:1][C:2]1[N:3]=[CH:4][CH:5]=[C:6]2[C:7]=1[C:11](=[O:13])[C:10]([C:16]1[CH:17]=[CH:18][C:19]([Cl:22])=[CH:20][CH:21]=1)=[CH:9][NH:8]2

Participants

3

Reactant 1

HCID 131732559HCID 131732559, compound

Product 1

HCID 87286061HCID 87286061, compound

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Procedure

Solid ethyl α-[[(2-chloro-4-pyridinyl)amino]methylene]-(4-chlorophenyl)acetate (4.0 g) was added in portions to refluxing phenylether (50 mL). After 20 min at reflux, the reaction was allowed to cool and diluted with hexanes. The precipitate that formed was collected and washed with hexanes. Purification by preparative RPHPLC gave the title compound as a light yellow solid.

Workup

  1. temperatureAfter 20 min at reflux
  2. temperatureto cool
  3. customThe precipitate that formed
  4. customwas collected
  5. washwashed with hexanes
  6. customPurification by preparative RPHPLC

Sources & evidence

ORD record
ord-001b17fbca6944c6b4ed039c929cbde9
Source dataset
uspto-grants-2015_03
Patent number
US08975407B2

Reaction notes

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