Hydrochloric Acid → HCID 86707301, compound

HRID 873498Notes

Reaction equation

HRID 873498 reaction equation
[CH2:1]([C:5]1([CH2:32][CH2:33][CH2:34][CH3:35])[C:17]2[CH:16]=[C:15]([N:18]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:14]=[CH:13][C:12]=2[C:11]2[C:6]1=[CH:7][C:8](Br)=[CH:9][CH:10]=2)[CH2:2][CH2:3][CH3:4].C([Li])CCC.[B:41](OC)([O:44]C)[O:42]C.Cl>O.C1COCC1>[CH2:1]([C:5]1([CH2:32][CH2:33][CH2:34][CH3:35])[C:17]2[CH:16]=[C:15]([N:18]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:14]=[CH:13][C:12]=2[C:11]2[C:6]1=[CH:7][C:8]([B:41]([OH:44])[OH:42])=[CH:9][CH:10]=2)[CH2:2][CH2:3][CH3:4]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 8470Trimethyl borateHCID 86061402HCID 86061402, compoundHCID 178418339Butyllithium

Product 1

HCID 86707301HCID 86707301, compoundYield 79.4%

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
-30 °C

Procedure

To a dry 100 mL two-neck flask containing 1.3 g (2.47 mmol) of compound 2 and 30 mL of dry THF was dropwise added 2.3 mL (3.71 mmol) of 1.6 M of n-butyl lithium under N2 at −78° C. while maintaining a good stirring. After stirring for 1 h, trimethyl borate (0.4 mL, 3.71 mmol) was added in one portion. The reaction mixture was then stirred for 1 h at −78° C. When the mixture was naturally warmed to −30° C., water and HCl (3 M) were added. Then the solution mixture was poured into water wad extracted with ethyl acetate (3×50 mL). The combined organic phase was dried over anhydrous sodium sulfate, filtered and evaporated to dryness under 35° C. The crude product was purified by silica gel column chromatography using dichloromethane and petroleum ether/ethyl acetate as eluent affording a light-yellow solid (0.96 g, 79%). 1H NMR (400 MHz, DMSO-d6, δ) 8.02 (s, 2H), 7.80 (s, 1H), 7.77 (d, J=7.6 Hz, 1H), 7.71 (d, J=8.4 Hz, 1H), 7.27 (t, J=7.6 Hz, 1H), 7.08 (d, J=1.6 Hz, 1H), 6.93-7.01 (m, 6H), 6.91 (d, J=2.0 Hz, 1H), 1.79-1.88 (m, 4H), 0.95-1.04 (m, 4H), 0.65 (t, J=7.4 Hz, 6H), 0.50-0.58 (m, 4H). 13C NMR (100 MHz, DMSO-d6, δ) 152.1, 148.9, 147.4, 146.8, 142.1, 136.1, 133.1, 129.4, 129.3, 128.2, 123.3, 122.7, 121.1, 119.1, 118.3, 54.3, 39.2, 25.8, 22.4, 13.8. MS (FAB) m/z 489.7 (M+).

Workup

  1. customat −78° C.
  2. temperaturewhile maintaining a good stirring
  3. stirringThe reaction mixture was then stirred for 1 h at −78° C
  4. extractionwad extracted with ethyl acetate (3×50 mL)
  5. dry with materialThe combined organic phase was dried over anhydrous sodium sulfate
  6. filtrationfiltered
  7. customevaporated to dryness under 35° C
  8. customThe crude product was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-1242ea133230485ebd63a1464490d8e9
Source dataset
uspto-grants-2015_03
Patent number
US08975419B2

Reaction notes

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