4-Methoxybenzylamine → ethyl 4-((4-chlorophenyl)((4-methoxybenzyl)amino)methyl)-1,5-dimethyl-1H-pyrazole-3-carboxylate

HRID 873830Notes

Reaction equation

HRID 873830 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](O)[C:9]2[C:10]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[N:11][N:12]([CH3:15])[C:13]=2[CH3:14])=[CH:4][CH:3]=1.[CH3:22][O:23][C:24]1[CH:31]=[CH:30][C:27]([CH2:28][NH2:29])=[CH:26][CH:25]=1>CCOC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:29][CH2:28][C:27]2[CH:30]=[CH:31][C:24]([O:23][CH3:22])=[CH:25][CH:26]=2)[C:9]2[C:10]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[N:11][N:12]([CH3:15])[C:13]=2[CH3:14])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 754524-MethoxybenzylamineHCID 117702851ethyl 4-((4-chlorophenyl)(hydroxy)methyl)-1,5-dimethyl-1H-pyrazole-3-carboxylate

Product 1

HCID 117702748ethyl 4-((4-chlorophenyl)((4-methoxybenzyl)amino)methyl)-1,5-dimethyl-1H-pyrazole-3-carboxylate

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Step 1.4 using ethyl 4-((4-chlorophenyl)(hydroxy)methyl)-1,5-dimethyl-1H-pyrazole-3-carboxylate (Step 25.2) and 4-methoxybenzylamine. tR: 3.99 min (HPLC 1); tR: 0.86 min (LC-MS 2); ESI-MS: 428 [M+H]+ (LC-MS 2); Rf=0.59 (EtOAc).

Sources & evidence

ORD record
ord-5ff9d7c68c004a348af42c4446e57f04
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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