HCID 117702781, compound → HCID 86294280, compound

HRID 873850Notes

Reaction equation

HRID 873850 reaction equation
[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([NH:10][CH:11]([C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=2)[C:12]2[CH:13]=[N:14][N:15]([CH:20]3[CH2:22][CH2:21]3)[C:16]=2[C:17]([OH:19])=O)[CH:3]=1>CCOC(C)=O>[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([N:10]2[CH:11]([C:23]3[CH:24]=[CH:25][C:26]([Cl:29])=[CH:27][CH:28]=3)[C:12]3[CH:13]=[N:14][N:15]([CH:20]4[CH2:21][CH2:22]4)[C:16]=3[C:17]2=[O:19])[CH:3]=1

Participants

3

Reactant 1

HCID 117702781HCID 117702781, compound

Product 1

HCID 86294280HCID 86294280, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-(((5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)amino)(4-chlorophenyl)methyl)-1-cyclopropyl-1H-pyrazole-5-carboxylic acid (Step 35.2). tR: 4.30 min (HPLC 1); tR: 0.98 min (LC-MS 2); ESI-MS: 415/417 [M+H]+ (LC-MS 2); Rf=0.33 (EtOAc); 1H NMR (400 MHz, DMSO-d6) δ ppm 0.99-1.10 (m, 2H) 1.17-1.30 (m, 2H) 3.42 (s, 3H) 3.83-3.94 (m, 1H) 6.11 (s, 1H) 7.21-7.29 (m, 2H) 7.32-7.38 (m, 2H) 7.41 (s, 1H) 7.88 (d, J=2.4 Hz, 1H) 7.92 (d, J=2.4 Hz, 1H).

Sources & evidence

ORD record
ord-fbd510ae85e24964b841976c5b443cd3
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

Loading…