HCID 117702678, compound → HCID 86294281, compound

HRID 873852Notes

Reaction equation

HRID 873852 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:20][C:21]2[CH:26]=[C:25]([CH3:27])[C:24](=[O:28])[N:23]([CH3:29])[CH:22]=2)[C:9]2[CH:10]=[N:11][N:12]([CH:17]([CH3:19])[CH3:18])[C:13]=2[C:14]([OH:16])=O)=[CH:4][CH:3]=1>CCOC(C)=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[C:9]3[CH:10]=[N:11][N:12]([CH:17]([CH3:18])[CH3:19])[C:13]=3[C:14](=[O:16])[N:20]2[C:21]2[CH:26]=[C:25]([CH3:27])[C:24](=[O:28])[N:23]([CH3:29])[CH:22]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 117702678HCID 117702678, compound

Product 1

HCID 86294281HCID 86294281, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-((4-chlorophenyl)((1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)amino)methyl)-1-isopropyl-1H-pyrazole-5-carboxylic acid (Step 36.5). tR: 4.31 min (HPLC 1); tR: 0.97 min (LC-MS 2); ESI-MS: 397 [M+H]+ (LC-MS 2); Rf=0.22 (EtOAc); 1H NMR (400 MHz, DMSO-d6) δ ppm 1.47-1.56 (m, 6H) 1.91 (s, 3H) 3.34 (s, 3H) 4.73-4.87 (m, 1H) 6.09 (s, 1H) 7.18-7.25 (m, 2H) 7.32-7.38 (m, 3H) 7.40 (s, 1H) 7.71 (d, J=2.7 Hz, 1H).

Sources & evidence

ORD record
ord-e38d8d1f81fa4c0d81612b4e2690e97e
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

Loading…