HCID 117702916, compound → HCID 86294478, compound

HRID 873858Notes

Reaction equation

HRID 873858 reaction equation
[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([NH:10][CH:11]([C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=2)[C:12]2[CH:13]=[N:14][N:15]([CH:20]([CH3:22])[CH3:21])[C:16]=2[C:17](O)=[O:18])[CH:3]=1>CCOC(C)=O>[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([N:10]2[CH:11]([C:23]3[CH:24]=[CH:25][C:26]([Cl:29])=[CH:27][CH:28]=3)[C:12]3[CH:13]=[N:14][N:15]([CH:20]([CH3:21])[CH3:22])[C:16]=3[C:17]2=[O:18])[CH:3]=1

Participants

3

Reactant 1

HCID 117702916HCID 117702916, compound

Product 1

HCID 86294478HCID 86294478, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 1 using 4-(((5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)amino)(4-chlorophenyl)methyl)-1-isopropyl-1H-pyrazole-5-carboxylic acid (Step 38.2). tR: 4.55 min (HPLC 1); tR: 1.02 min (LC-MS 2); ESI-MS: 417 [M+H]+ (LC-MS 2); Rf=0.41 (EtOAc); 1H NMR (400 MHz, DMSO-d6) δ ppm 1.47-1.55 (m, 6H) 3.43 (s, 3H) 4.75-4.86 (m, 1H) 6.13 (s, 1H) 7.21-7.28 (m, 2H) 7.34-7.40 (m, 2H) 7.42 (s, 1H) 7.89 (d, J=2.7 Hz, 1H) 7.94 (d, J=2.7 Hz, 1H).

Sources & evidence

ORD record
ord-7f51d5b3b24c44369ff298678564ea1f
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

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