4-Chlorobenzaldehyde → ethyl 4-((4-chlorophenyl)(hydroxy)methyl)-1-cyclopropyl-3-(trifluoromethyl)-1H-Pyrazole-5-carboxylate

HRID 873876Notes

Reaction equation

HRID 873876 reaction equation
[CH:1]1([N:4]2[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:7][C:6]([C:14]([F:17])([F:16])[F:15])=[N:5]2)[CH2:3][CH2:2]1.[Cl:18][C:19]1[CH:26]=[CH:25][C:22]([CH:23]=[O:24])=[CH:21][CH:20]=1>CCCCCC>[Cl:18][C:19]1[CH:26]=[CH:25][C:22]([CH:23]([OH:24])[C:7]2[C:6]([C:14]([F:17])([F:16])[F:15])=[N:5][N:4]([CH:1]3[CH2:3][CH2:2]3)[C:8]=2[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 77264-ChlorobenzaldehydeHCID 117702900ethyl 1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylate

Product 1

HCID 117702683ethyl 4-((4-chlorophenyl)(hydroxy)methyl)-1-cyclopropyl-3-(trifluoromethyl)-1H-Pyrazole-5-carboxylate

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Step 40.2 using ethyl 1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylate (Step 44.1) and 4-chlorobenzaldehyde. tR: 1.29 min (LC-MS 2); ESI-MS: 389 [M+H]+ (LC-MS 2); Rf=0.12 (hexane/15% EtOAc).

Sources & evidence

ORD record
ord-fb005f8ea2ca466cb018d10349654917
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

Loading…