4-Chlorobenzaldehyde → HCID 117702714, compound

HRID 873893Notes

Reaction equation

HRID 873893 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[C:7]([O:9][CH3:10])[C:6]([N:11]2[C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[C:14](I)[C:13]([CH3:22])=[N:12]2)=[CH:5][N:4]=1.[Cl:23][C:24]1[CH:31]=[CH:30][C:27]([CH:28]=[O:29])=[CH:26][CH:25]=1>CCCCCC.CCOC(C)=O>[Cl:23][C:24]1[CH:31]=[CH:30][C:27]([CH:28]([OH:29])[C:14]2[C:13]([CH3:22])=[N:12][N:11]([C:6]3[C:7]([O:9][CH3:10])=[N:8][C:3]([O:2][CH3:1])=[N:4][CH:5]=3)[C:15]=2[C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:26][CH:25]=1

Participants

4

Reactant 2

HCID 77264-ChlorobenzaldehydeHCID 117702818HCID 117702818, compound

Product 1

HCID 117702714HCID 117702714, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Step 1.3 using ethyl 1-(2,4-dimethoxypyrimidin-5-yl)-4-iodo-3-methyl-1H-pyrazole-5-carboxylate (Step 52.2) and 4-chlorobenzaldehyde at RT for 30 min. tR: 5.02 min (HPLC 1); tR: 1.11 min (LC-MS 2); ESI-MS: 433 [M+H]+ (LC-MS 2); Rf=0.38 (hexane/EtOAc 1:1).

Sources & evidence

ORD record
ord-c2f7d9c07d6e4a4f96ceab85d2203086
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

Loading…